PRO Gel 5000 Toothpaste with Nano-HA
Purposeful Innovation, Science-Backed Formulations
The remineralizing toothpaste you’ve been waiting for! The only toothpaste to combine 1.1% fluoride with medical-grade nano-hydroxyapatite (nanoXIM) for unmatched remineralizing power. Our soothing, low-abrasion gel also features patented elevated pH technology to neutralize acids. The result? A cleaner, stronger, healthier smile backed by real science. See the research studies and case studies below to discover what makes our Pro Gel unlike anything else.
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- Description
- Directions
- Ingredients
- FAQs
- Research and Case Studies
PRO Gel 5000 Toothpaste with Nano-Hydroxyapatite
2.4 oz tube (approximately 136 doses), recommended for ages 6+, and made in the USA!
- Mild and moistening for dry mouth
- Proudly contains nanoXIM by FLUIDINOVA, the only nano-hydroxyapatite globally recognized and approved for oral care by the European Scientific Committee on Consumer Safety
- 1.1% Sodium Fluoride
- 25% Xylitol
- Elevated pH technology
- Low abrasion (RDA 40)
Use once daily as your normal dentifrice or as directed by your dental professional. Apply a thin ribbon of gel dentifrice to toothbrush and brush thoroughly on all tooth surfaces for at least one minute. Adults, expectorate gel after use and for best results do not eat, drink or rinse for 30 minutes. Adolescent patients, ages 6-17, expectorate after use and rinse mouth thoroughly. Instruct children under 12 to minimize swallowing. Supervise children as necessary until capable of using without supervision.
MINT
Active Ingredient: Sodium Fluoride, 1.1% (w/w); Other Ingredients: Glycerin, Hydrated Silica, Hydrogenated Starch Hydrolysate (HSH), Hydroxyapatite, Hydroxyethyl Cellulose, Menthol, Natural Flavors, Polysorbate 20, Potassium Sorbate, Saccharin, Sodium Benzoate, Sodium Bicarbonate, Sodium Hydroxide, Sodium Lauryl Sulfate, Water, Xylitol
CITRUS
Active Ingredient: Sodium Fluoride, 1.1% (w/w); Other Ingredients: Glycerin, Hydrated Silica, Hydrogenated Starch Hydrolysate (HSH), Hydroxyapatite, Hydroxyethyl Cellulose, Natural and Artificial Flavors, Polysorbate 20, Potassium Sorbate, Saccharin, Sodium Benzoate, Sodium Bicarbonate, Sodium Hydroxide, Sodium Lauryl Sulfate, Water, Xylitol
How well does the CariFree Gel 5000 remineralize?
A recent 2022 study showed that “after 3 days the CariFree Pro Gel 5000 achieved a mean %SMHR of 63%, compared to 38% for the negative control. Statistical analysis confirmed a significant difference, with Pro Gel 5000 providing ~67% higher than the mean %SMHR value achieved by the negative control.”
Why do you use Fluoride with nano-hydroxyapatite instead of n-HA alone?
Fluoride and nano-hydroxyapatite (n-HA) each play important but distinct roles in supporting enamel health. Used together, they help promote more complete remineralization than either ingredient alone. Fluoride helps form a stronger, more acid-resistant mineral on the tooth surface, while nano-hydroxyapatite works within the enamel to help replenish lost minerals and reinforce its natural structure. This combination helps strengthen and smooth enamel for a cleaner, healthier smile.
How much nano-hydroxyapatite is in your gel?
While we don’t release final concentrations of our formulas, our company focuses on quality and size, as studies show that the most bioavailable size of nano-hydroxyapatite particles are 20 nanometers, and rod-shaped particles are the safest and vital for remineralization. Our gels use high-grade, rod-shaped particles that present a length of <50nm and width of <10nm to ensure effective remineralization. Since 2012, we have used nanoXIM by FLUIDINOVA in our products, the only nano-hydroxyapatite globally recognized and approved for oral care by the European Scientific Committee on Consumer Safety.
How is your 5000 ppm toothpaste different from other 5000 ppm toothpastes?
CariFree Gel 5000 is the only prescription-strength toothpaste that also contains medical grade nano-hydroxyapatite.
How effective is the Gel 5000 at changing the pH in a patient's mouth?
pH is the central component of all CariFree products, and the Pro Gel 5000 is no exception. Maintaining a neutral or alkaline pH helps support remineralization and protects teeth from acid attacks that contribute to dental caries. A recent independent study conducted by Intertek found that:
“CariFree PRO Gel 5000 toothpaste demonstrated effective pH-buffering capabilities in dental plaque, maintaining a range crucial for enamel remineralization during a 20-minute sucrose challenge. This performance indicates the toothpaste’s potential to create an oral environment that favors remineralization and counters the acidogenic effects typically induced by sugar intake.” (link to full study)
PRO Gel 5000 Intertek Lab pH Study
“CariFree PRO Gel 5000 toothpaste demonstrated effective pH buffering capabilities in dental plaque, maintaining a range crucial for enamel remineralization during a 20-minute sucrose challenge. This performance indicates the toothpaste’s potential to create an oral environment that favors remineralization and counters the acidogenic effects typically induced by sugar intake.”
PRO Gel 5000 Intertek Lab Remineralization Study
“After 3 days the CariFree Pro Gel 5000 achieved a mean %SMHR of 63%, compared to 38% for the negative control. Statistical analysis confirmed a significant difference, with Pro Gel 5000 providing ~67% higher than the mean %SMHR value achieved by the negative control.”
PRO Gel 5000 Indiana University RDA Study
Hara, A. T., & Ding, R. (2024). Final report: Determination of the relative dentin abrasion level of dentifrices (Report No. 24-RDA-104). Indiana University School of Dentistry, Oral Health Research Institute.
The study concluded that the PRO Gel 5000 has an RDA of 48.9 +/- 1.02.
A Salivary Diagnostics-Guided Approach to High-Risk Caries Management
Managing Pediatric Caries with Salivary Diagnostics and Biofilm Shifting